Too much ethanol is not good for cars not equipped to handle it - messes up fuel lines, pumps, etc.
REALLY bad for watercraft.
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I've used MOA in engines for years as a mechanic and it seems to work in reducing friction. i also use it mixed with 5w30 synthetic motor oil for a lube for all my guns and the carbon seems to clean off easier(could be my imagination} and the actions do seem smoother.
The 44k never worked that well for me so i never pushed the product. Lucus fuel injection cleaner worked a little better and was cheaper. YMMV
I use seafoam for fuel and I use atf before an oil change as a sludge remover.
Adding stuff to fuel...in most cases can't hurt, and if used as instructed, helps. I add Lucas fuel injection cleaner to my fuel when I change the oil. I have three vehicles with V8s and use good filters and synthetic oil. With over 180K on the 2003, still in great shape.
Adding stuff to your motor oil...not a good idea. Oils have specific packages in them and thickening or thinning or adding a package that sets up an acid-base reaction in your engine...yeah, that won't be fun for you. Even mixing (as in quarts) is not a good idea. For older engines with sludge issues, adding a solvent (like BG Purge) can be a good thing and help. White Gas is cheaper and about the same thing. I used White Gas in my old Mopars at every oil change.
Using a quality oil filter and changing fuel filters is better long term than additives.
I like 44k, but I want to second not leaving it in the tank. Might be coincidence but I've had 2 mechanical fuel pump go after letting a car sit with it in lines. One was a pretty new pump. I've also read that Sea Foam is similar in effectiveness and 1/3 the cost if bought on special. I've read a couple factory maintenance recommendations that recommend adding Techron every 3000 miles. Kia was the most recent that I can remember.