Originally Posted by
JohnnyEgo
Only problem with starting with a .22 is that there is no way to go down if she doesn't care for it. With adults who haven't shot before, I like to start with a 6" .357 loaded with .38 wadcutter. Very mild recoil, and sets a reasonable expectation of every other caliber to come. Once she has gotten over the initial sound and fury, you can go to the .22 to practice fundamentals.
Only other piece of advice I have is to take a mutual friend or someone else with you, and let them offer advice and correction. Your only function should be to offer encouragement and support. Otherwise, couples tend to bring too much baggage into instruction, which is both dangerous and counter productive.