I use my AR for H/D. Keep nailin' them until they are no longer a threat. Even 5.56 vmax rounds penetrate soft armor. Plus with the AR a quick headshot is alot easier (for me) than with a pistol.
[AR15]
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Most who posted here have been fixated on there being one assailant and placing 2 to the chest and one to the head. I'm more concerned about there being multiple assailants. I once heard a dispatch tape of an off-duty San Diego County Deputy who pissed off a motorcycle gang and was chased into a vacant building. He had a (then new) S&W with a fourteen or fifteen round capacity. On the tape he was telling the dispatcher that fourteen or fifteen had him cornered, hold on, bang, one more down. Please call my sergeant at (number) and tell him, hold on, bang, there's another one down, tell him I'm going to be late for my shift. Tell my back-up that things are getting kind of tense here, I'm down to my last 5 ir 6 rounds. He was nicknamed the Ice Man.
So those other two "misses' could be potential murder charges. The right state of mind would be to not take the shot unless you are sure you will hit your target.
Remember, a pistol is a DEFENSIVE weapon. If you are truly in combat, you shouldn't be using a pistol.