I use a 1/4 tank of E85 to bump up the octane and clean the fuel system. The user manual calls for 87 octane and I use 85 octane regularly. I also use Techroline fuel injection cleaner every other tank. Engine is modded with a aluminum intake manifold. Old intake was plastic. The injectors were spotless when I installed the manifold. Engine is a Ford 4.6L V8.
I do lose some MPG, but I seem to gain some performance.
The computer seems to handle the air/fuel ratio very well and all the O2 sensors this were replaced this year.
'03 and later versions are all E85 Flex Fuel vehicles from the factory. 2012 was the last year of MGM's and Crown Vic's.
I have never tried more than a quarter tank of E85. I have never gotten a CEL from this and a live reading of the 02 sensors is nominal. Car has 66K miles.

