If you are talking about the 6.5Grendel and the 6.8 SPC, yes, different bolts and different mags. The 6x45 is a pretty decent cartridge. It is actually one you can reasonably use as an all-around AR if you reload since the Nosler Varmageddon is about $165/1K.
If you want a 6.5 in the same vein as the 6x45, give me about a month and I will have my prototype up and running. Everything the same as the .223/5.56 except the barrel. Bullets are more coin, and heavier, but the ballistics are very promising.