Excellent thread and great OP. Like many that have already posted, I too have owned and shot a myriad of different handgun platforms. In recent years, I have streamlined all my handguns to 9mm. For me it was for the reasons of capacity, affordable to reload, bulk ammo cost and modern 9mm defense ammo has come a VERY long way in the 9mm cartridge. I own both Glock and M&P series pistols. The grip angle is slightly different between the platforms, but I truly shoot both equally well. Not everyone's requirement/job for their handgun is the same. For me, they need to run in damn near any weather condition, dirty or clean. The Glock and M&P series pistols have me those requirements. I also like the modularity of the platforms. The benefit of the Glock over the M&P in my opinion is the Glock is significantly easier to work on. Knowing not one gun is the "be all, end all" of platforms is really a level of maturity few have achieved.
Stay frosty.