make sure the coolant is correctly treated to avoid cavitation
Or run CAT ELC coolant, no need to treat it. That's what I do. There are other coolants that come with ELC in them I'm sure.
Mine is an 01 F250 and just last year I had to do a water pump, for the first time.
I also added the tranny cooler that normally goes on the 06 models to add a bit more cooling for my auto tranny, at the same time that I had it rebuilt at 105,000.
Other than an occasion glow plug replay, oh and I had to take mine in for the CPS recall and haven't had that go out since. Tie rod ends done once also.
I'm nearing 185,000 now. I don't plan on ever buying another 3/4 ton because this one will last my life time.