Research the actual ported barrel velocity of a 125 grain .357 from a four inch revo compared to a five inch 124 grain 9MM 1911. With the right reloading components your 38 Super can beat that. 9mm +P is really close to a short barrel .357.
I own several 45 ACP revolvers. They are big heavy six shot N frames. If your going to carry that weight get a 44 Remington Magnum and reload for it. Everyone I have talked to with a alloy 45 ACP or 44 N frame has regretted the choice. To big and recoil is nasty.
Pocket carry a five shot revo if you want to mess with that platform. My everyday carry is a alloy J frame.