I've found that most quality guns will easily run 10k rounds through them. If the gun doesn't fit my hand to where the pistol moves when the trigger breaks, I won't be able to shoot it well from round 1 thru 10k. There are certain makes and models that don't end up on my short list for that reason. For example, the XDs and S&W Shield are too narrow and don't anchor well in my strong hand. The classic Walther PPS does.
I have a Gen 3 G19, and the slide rubs the web of my thumb. I found the Walther PPQ doesn't, is pretty much the same size as the G19, and has a great trigger. The only Glock that I've found works for me is the oddball G36. Not all anatomy comes out of a single template and platform does matter.