When I sold my S10, they went to get cash, and while they were gone I removed the license plates, registration and other personal stuff from the truck, and dug out the title. They handed me the cash, I counted it out and when I confirmed it, I signed the title and handed it and the keys over to them.

If they're using a check, meet at their bank to verify the funds are available (and cash it there).

If getting a bank loan, meet at that bank and the title goes to them.