With regards to your first point, I don't think that's true anymore. At least in the sense that both turbo boost and hybrid technology can add the benefits of more displacement without the weight penalties of additional displacement.
With regards to the second, sweating fuel mileage while towing is indeed an exercise in futility.
But many tow vehicles (including mine) don't tow 100% of the time - more like 50% or even less. So wanting to maximize MPG for the times when I'm NOT towing makes good sense, as long as doing so doesn't compromise the towing aspect.
That, again, is the benefit of the turbo: It provides power when you need it (and the high fuel consumption required to get that power) but when you don't need it, it goes back to being a mild V6.
Of course, even "improved MPG" isn't the whole story, is it? After all, when we talk about "saving fuel" what we REALLY want to do is save MONEY.
So then I would have to factor whether a boosted V6 that gets better MPG - but requires more expensive premium fuel - is a better deal than an NA V8 that doesn't do quite as well in terms of fuel economy - but that will burn cheap, rot-gun 85 octane.