Yes. I use 3M chemical filters with the charcoal cartridge, cotton pad filter, and added a fine paper filter on top to capture larger particulates like latex. The paper filter is additional that extends life of the outer cotten filter, both for spraying paints and organophosphate+ chemicals/tree oils in the orchard. Full and multiple layer coverings can protect and get the work done.
The mid range sprayers available now may work fine. I don't have experience with them and appreciate your comment. I have used many different sprayers including the cheap electric units that always make a terrible mess that are a waste of time and money from beginning to end. For me, quality tools rule. I'm an advocate for investing in efficiency, safety and long term economy.