600 yards is a very long shot. Over a 1/4 mile.

Depending on how many vehicles are trying to get to my garden, I'd likely wait until they are closer.

Weapon of choice? Mine or any?

Any weapon would be a semi-auto .50 BMG or if we are going super unlimited, a turret mounted M2, chain-fed full-auto with 600k rounds of ammo and a cute girl to help feed the belts.

My guns? Scoped 30-06. Radiator if head on. Top of the front tire from the side. Both shots could damage a lot of equipment if not dead solid hits. If they keep coming, switch to the .450 Bushmaster at around 200 yards.