Seem to be sticking to my 7 shot 686 with 2.5 inch barrel for just about everything these days. It's the nightstand gun, truck gun, IWB gun. The others are all locked away. I'd be too afraid someone would steal them to leave them out when I wasn't home.
Guess I could load up that 460 weatherby that I'm trying to sell. It's not in the safe. 500 grain FMJ doing 2,600 fps might be hard on the neighbors for several houses in a row though.