I carry my G23 in an IWB holster between 4 and 5oclock. Theres a round in the chamber and the mag is topped off, gotta be ready for anything and if I have to draw, I'm going to pull the trigger, and when I draw pulling the trigger will be the only thing on my mind. Not racking the slide. Not loading a mag. Not remembering if I have one chambered. Not hitting a safety (hence why I won't carry a 1911 or other non-safe action pistol).
(I voted Chambered and Safety On, because it's a Glock and the safety is always on)