The only way to get a "Whisper" is through SSK. They use 221 fireball brass to form the 300 Whisper. If you use 223 brass in a "Whisper" you will need to neck turn your brass. Most of the other Fireballs or 300/223 will not require this step. A barrel swap and gas port location change will be the only change from a traditional 5.56/223 AR.
SSK makes a great firearm but you pay for that developement and reliability.
Most non SSK guns require a little tweaking. Make sure you get yours with the gas port in the pistol location if you plan to shoot sub-sonic. This will require a gas block under the forward handguard like the "Dissipator".
Personally I can't justify paying SSK for a propietary design that has been available long before they "Designed" it.
I also did not go with a 300/221. I just couldn't justify a neutered super-sonic round and I don't like the energy numbers on the sub-sonic rounds.
I went with a 7.72x39 for super-sonic and if I wanted a sub-sonic I would get a 458 SOCOM. If more 30 cal energy and velocity is needed, Olympic is making a 30 OSSM which is a 30 cal version of the WSSM which exceeds 30-06 in velocity and energy with a 180 grain bullet.
If you need more info on the "Whisper" or it's equivalents, www.quarterbore.net is probably the net's leading source of unbiased information. In the forum there is a whole section dedicated to these designs.