I found someone else saying it was "for sure" going to be a polymer-framed single action (with a built-in laser in the ejector rod...I'm hoping that's a joke).

How about a SR-308? That'd be cool.

1911-2011???

My bet is on a 1911.

On a related Ruger note I see they are now offering SR-556 uppers for sale. That's cool.