I'm a big fan of my Ruger Single Six Convertible:
http://www.ruger.com/products/newMod...le/models.html

Pros for ME:
1. Adjustable sights
2. Nice single action trigger
3. Good sight radius
4. Multiple calibers .22 S, L, LR, and Mag.
5. Stainless Steel
6. Will send just about anything down range. ie. At my range, I can grab rounds out of the squib/dud bucket, load them and it sends them without hesitation. My thought was that if I had to scrounge for ammo, I didn't want a picky gun.

Con for me (Defensively Speaking):
1. All of the Single Action Revolver attributes not conducive for defensive use.