I plan on picking up a 4S after training (late Feb/early March). Had the 3G from when they first came out till I killed it a couple months ago.
Is it better than a Droid? Maybe, maybe not. But I know I like and am familiar with the interface and I don't want to learn a new one, and I know I won't have any issues getting it to play nice with my computer (MacBook), and my sim card already has the iPhone plan on it from my 3G, so there's really no contest.