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Aim for the driver. Any barrier blind round that will reliably punch through auto glass and car body steel at those distances, 7.62x51mm NATO or equivalents at the minimum. Fired from a weapon with a standard capacity magazine or better yet a belt fed, definitely at least from a semi-automatic firearm.
If you did not have to shoot it; but deliver it - I would say paint; smoke, even water vapor would work if done right.
To just kill the motor; a very fine powder mist to block the air intake; hmm; what that powder is comprised of could have different impacts on the quality of life for a normal motor.
If you must have to shoot something and you can funnel the traffic; tannerite
Bad guys will start looking for a corvair after reading this information
At 600 - 1000 yds, I'd think at least .416 Barrett... 100 yds, .458 SOCOM
This should do it...
https://nationalinterest.org/sites/d...%20%281%29.jpg
Well, if'n it was something I just HAD to do, and I had time to set up for it, I reckon my M1 Garand and some M2AP would work just fine.