I carry a Sig P229 9mm as my EDC, I always carry with one in the chamber and hammer back... reasoning, I've trained over and over for the lighter trigger pull.
I didn't have a problem, but then again I got the whole deal in one go, MBUS and EOTech, so I just co-witnessed my iron sights after dialing in the EOTech and then removed the HWS to confirm and it was dead on. I've heard the same but I don't know for sure if the heightened rail actually does mess up your zero.
ETA: Adjust your zero- I used a 25m->100m zero sheet (shoot at 25m and it is good up to 100m).






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